© 2019 by VIOBAC

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OUR SOLUTION

Our idea is to implement UV-technology directly on the catheter tube through a small click-on medical device. 

The solution prevents bacteria from getting into the patients urinary tract system - and will thereby prevent unnecessary urinary tract infections from even happening when using a catheter.

Catheter-associated urinary tract infections (CAUTIs) have been reported as the most common hospital acquired infection in the world being responsible for 40% of all hospital infections, with more than 1 million cases per year in the US alone. 

Approximately 25 % of hospitalized patients will undergo urinary catheterization, and nearly 30 % of these will develop catheter-associated urinary tract infection (CAUTI), or another non-infectious complication of catherization.

 

Escherichia coli (E. coli) is the most common etiological agent followed by Klebsiella-, Serratia-, Citrobacter-, Enterobacter-, Enterococcus-, and coagulase-negative staphylococci species. The risk of getting a urinary tract infection (UTI) among catherized patients is estimated to be up to 10 % per day, while 100 % are expected to have a UTI after 3 weeks of catherization. The aforementioned bacteria are capable of adhering to catheter surfaces in bacterial communities known as biofilm, having greater resistance to the natural immune system of the host as well as being almost resistant to antimicrobials and virtually impossible to eradicate without removing the catheter.

Clinical outcomes

CAUTI can lead to complications as prostatitis, epididymitis, and orchitis in males, and cystitis, pyelonephritis, bacteraemia, endocarditis, vertebral osteomyelitis, septic arthritis, endophthalmitis, and meningitis in patients. Besides the aforementioned symptoms, CAUTI can lead to discomfort to the patient, prolonged hospital stay, and increased cost and mortality. It has been estimated that the mortality rate increases with 50 % and more than 13,000 deaths are associated with UTIs in the US each year. 

 

Antimicrobial resistance

Indwelling urinary catheters are important reservoirs of different multiresistant gram-negative bacteria and treating CAUTI with antibiotics will only promote the emergence of resistant microorganisms. Due to frequent antimicrobial exposure, antimicrobial resistant bacteria are more commonly isolated from catheterized urine samples. In fact, the urine of residents with chronic indwelling urinary catheters was found to be the most common site of isolation of resistant gram-negative organisms in nursing home settings

Economical impact 

Newly published research suggests the actual costs of CAUTIs are much higher than earlier anticipated.

Peer-reviewed research published in 2018 in the American Journal of Infection Control by researchers Christopher S. Hollenbeak, PhD, professor of surgery and public health sciences at Pennsylvania State University, and Amber L. Schilling, PharmD, MEd, research analyst at the Penn State College of Medicine, indicates the true costs depends on the settings and perspectives in which the CAUTIs occurred. The systematic review identified 4 studies estimating the costs associated with CAUTIs in the United States since the year 2000, and the reported attributable costs of CAUTIs are ranging from $7,670 in inpatient and outpatient costs to Medicare, to $10,197 in inpatient costs to Medicare for ICU patients. The U.S. Department of Health & Human Services’ Agency for Healthcare Research and Quality has estimated the additional hospital inpatient costs associated with CAUTI based in six studies with costs estimated ranging between $4,694-$29,743 with a mean of $13,793. 

The cost of a CAUTI ranges widely depending on population, patient acuity, and cost perspective, leading to large discrepancies. Nevertheless, there are no doubt that the expenses are too high. 

INTRODUCTION

"Approx. 130.000 catheters are inserted per year at Danish hospitals alone, but there exists no proper solution to prevent the bacterial infections associated with this - we aim to change this."

PREVENTING URINARY TRACT INFECTIONS

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